Comparison of Manuka Honey Dressing versus Normal Saline Dressing on the outcome of Diabetic Foot Ulcers

Abstract

Objective: Diabetic foot ulcers (DFUs) are common complications of diabetes, leading to infections and potential amputations. The Wagner Classification system is used to assess the severity of DFUs. Various dressing methods, including honey-impregnated dressings, have been explored for wound healing. However, high-quality research comparing honey dressings to conventional treatments is limited. This study aimed to compare the efficacy of Manuka honey-impregnated dressings with conventional saline dressings for DFUs, using the Wagner Classification.

Methodology: An observational cross-sectional study was conducted at Services Hospital Lahore from January 2023 to December 2023, with ethical approval. Diabetic patients aged 12-65 years with Grade 1 or 2 DFUs were included. A total of 90 patients were randomly assigned to two groups: Group A received Manuka honey dressings, and Group B received conventional saline dressings. After 4 weeks of follow-up, wound cultures were taken, and efficacy was determined based on the presence of bacterial growth. Data was analyzed using SPSS, with a chi-square test for post-stratification.

Results: The honey dressing group showed a higher efficacy rate, with 44 (97.8%) patients achieving sterile cultures, compared to 37 (82.2%) in the saline dressing group (p = 0.014). Stratification analysis revealed the difference was significant in male patients.

Conclusion: Manuka honey dressings significantly improve the healing of diabetic foot ulcers compared to conventional saline dressings, particularly in male patients. Honey-impregnated dressings could be a valuable alternative for DFU management, promoting faster healing and reducing infection risk.