Immunohistochemical Expression of Vitamin-D Receptor in Oral and Skin Squamous Cell Carcinoma of a Black African Subpopulation

Authors

  • AO Adisa Oral Pathology Department, College of Medicine, University of Ibadan, Nigeria
  • SE Udeabor Frankfurt Orofacial Regenerative Medicine (FORM) Lab, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of Goethe University Frankfurt, Frankfurt am Main, Germany
  • GO Ogun Pathology Department, College of Medicine, University of Ibadan, Nigeria
  • A Orlowska Frankfurt Orofacial Regenerative Medicine (FORM) Lab, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of Goethe University Frankfurt, Frankfurt am Main, Germany
  • RA Sader Frankfurt Orofacial Regenerative Medicine (FORM) Lab, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of Goethe University Frankfurt, Frankfurt am Main, Germany
  • S Ghanaati Frankfurt Orofacial Regenerative Medicine (FORM) Lab, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of Goethe University Frankfurt, Frankfurt am Main, Germany

DOI:

https://doi.org/10.55320/mjz.44.2.257

Keywords:

Immunohistochemistry, Vitamin-D, Squamous cell carcinoma, African

Abstract

Objective: The nuclear vitamin D receptor (VDR) is involved in multiple pathways that have a role to play in the biology of cancer. Recent evidence indicates that the active form of vitamin D (1alpha, 25-dihydroxycholecalciferol) (VD) exhibits several anti-growth effects. Thus it is useful as an antineoplastic agent in several human malignancies. We aim to analyze the expression of VDR in skin and oral squamous cell carcinomas (skin SCC and OSCC) from a black African sub-population to determine potential for active VD therapy in such patients.
Design: Nineteen formalin fixed paraffin embedded (FFPE) blocks of OSCC and 15 Skin SCC FFPE were prepared for Abcam Rabbit polyclonal Anti- Vitamin D Receptor antibody ChIP Grade (ab3508). Nuclear brown staining was considered as positive for VDR. The Sinicrope scoring method was used to evaluate the stained epithelial cells. All slides were viewed with a Nikon ECLIPSE 80i microscope and microphotographs recorded.
Results: Among 15 moderately differentiated OSCC 7 (46.7%) showed moderate to strong positivity for VDR, while 8 were weak or negative for VDR. Among 10 well-differentiated SCC of the skin, 8 (80%) cases showed moderate to strong VDR positivity, while 2 cases showed weak expression. Overall, approximately the same number of OSCC (9 cases) and Skin SCC (10 cases) expressed moderate to strong positivity for VDR.
Conclusion: In our study, we noted that the OSCC and skin SCC have similar number of cases expressing moderate to strong positive staining for VDR. Thus we suggest that the chemotherapeutic role already established for VD is of relevance in OSCC and skin SCC in black Africans.

 

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Published

11-06-2017

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Section

Original Article

How to Cite

Immunohistochemical Expression of Vitamin-D Receptor in Oral and Skin Squamous Cell Carcinoma of a Black African Subpopulation. (2017). Medical Journal of Zambia, 44(2), 64-68. https://doi.org/10.55320/mjz.44.2.257

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