A case series report of Tuberculosis patients with Vitamin D deficiency in Zambia
Abstract
An association of Vitamin D deficiency with Tuberculosis remains a valid assumption. It has been observed that TB is highly prevalent in certain ethnic groupings and regions of the world. Populations with darker skins are prone to vitamin D deficiency. The regions inhabited by people with darker skin coincides with high TB burden settings. Vitamin D has a key role in immune-modulation of the host response to Mycobacterium Tuberculosis infection. Studies have demonstrated early sputum culture conversion to negative, clinical recovery and radiological improvement with Vitamin D supplementation. However, there is currently no consens us on the advantages of this supplementation in TB treatment. We present the first case series report of pulmonary TB patients with severe deficiency of Vitamin D in Zambia. Additional data from randomised control studies is warranted.
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