A case series report of Tuberculosis patients with Vitamin D deficiency in Zambia

  • P Lungu Department of Medicine, University Teaching Hospital-Lusaka, Zambia
  • S Lakhi Department of Medicine, University Teaching Hospital-Lusaka, Zambia
  • K Mateyo Department of Medicine, University Teaching Hospital-Lusaka, Zambia
  • E Mubiana Department of Medicine, University Teaching Hospital-Lusaka, Zambia
  • P Mwaba Department of Medicine and Directorate of Research and Post-graduate studies, Lusaka Apex Medical University
Keywords: Immune Modulation, Mycobacterium Tuberculosis, Vitamin D

Abstract

An association of Vitamin D deficiency with Tuberculosis remains a valid assumption. It has been observed that TB is highly prevalent in certain ethnic groupings and regions of the world.  Populations with darker skins are prone to vitamin D deficiency. The regions inhabited by people with darker skin coincides with high TB burden settings. Vitamin D has a key role in immune-modulation of the host response to Mycobacterium Tuberculosis infection. Studies have demonstrated early sputum culture conversion to negative, clinical recovery and radiological improvement with Vitamin D supplementation. However, there is currently no consensus on the advantages of this supplementation in TB treatment. We present the first case series report of pulmonary TB patients with severe deficiency of Vitamin D in Zambia. Additional data from randomised control studies is warranted.

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Published
2017-09-14
Section
Articles