The use of Neurobion® Forte in the Treatment of Pellagra in an adult on anti-TB treatment: A case report from Lusaka, Zambia

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  • Sarah Nyangu Ministry of Health
  • MARY KAGUJJE Centre of infectious diseases and research in Zambia, CIDRZ
  • PATRICK LUNGU Ministry of Health
  • KELVIN ZIMBA Ministry of Health
  • LOPHINA CHILUKUTU
  • MONDE MUYOYETA
Keywords: Pellagra, Isoniazid, Niacin, Vitamins B1, B2, B3, B6 and B12, Neurobion® Forte

Abstract

Abstract

The deficiency of Niacin and/or its precursor amino acid, Tryptophan can result in a disease called Pellagra. Isoniazid (INH), a key drug used in tuberculosis (TB) treatment  has been associated with pellagra particularly in developing nations where poor nutritional status is highly prevalent among its people.We report a case of pellagra with classical dermatological manifestations (hyperpigmented skin lesions around the neck), on the face, and external surfaces of the upper limbs) in a black African HIV negative adult  female, on TB treatment for 11 weeks managed with a combo of Vitamin B1 - 10mg, Vitamin B2 - 10mg, Vitamin B3 - 45mg, Vitamin B5 - 50mg, Vitamin B6 - 3mg and Vitamin B12 - 15mcg (Neurobion® Forte) with noticeable response to the treatment within one week.

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Author Biographies

MARY KAGUJJE, Centre of infectious diseases and research in Zambia, CIDRZ

TB CLINICAL CARE SPECIALIST

TB DEPARTMENT, CENTRE FOR INFECTIOUS DISEASES AND RESEARCH IN ZAMBIA

PATRICK LUNGU, Ministry of Health

NATIONAL NTP MANAGER

MINSTRY OF HEALTH

KELVIN ZIMBA, Ministry of Health

CONSULTANT PEADIATRICIAN

TB SPECIALIST/COORDINATOR

MINSTRY OF HEALTH

LOPHINA CHILUKUTU

CLINICAL OFFICER

TB DEPARTMENT

CENTRE OF INFECIOUS DISEASES AND RESEARCH IN ZAMBIA

MONDE MUYOYETA

INFECTIOUS DISEASES EPIDEMIOLOGIST

TB PROGRAMS DIRECTOR

CENTRE OF INFECTIOUS DISEASES AND RESEACH IN ZAMBIA

Published
2021-04-06
How to Cite
Nyangu, S., KAGUJJE, M., LUNGU, P., ZIMBA, K., CHILUKUTU, L., & MUYOYETA, M. (2021). The use of Neurobion® Forte in the Treatment of Pellagra in an adult on anti-TB treatment: A case report from Lusaka, Zambia. Medical Journal of Zambia, 48(1), 58 - 62. Retrieved from https://mjz.co.zm/index.php/mjz/article/view/757
Section
Case Reports