Antimicrobial stewardship and oxazolidinones use, a consideration for a Zambian health system

  • Warren Chanda Mulungushi University
  • John Amos Mulemena Mulungushi University
  • Mespa Manyepa Copperbelt University
  • Kingsley Kamvuma Mulungushi University
Keywords: Oxazolidinone, Linezolid, Antimicrobial stewardship, antimicrobial resistance, Antibiotics, Zambia


Antimicrobial stewardship is the organized and systematic way of educating and enforcing evidence-based prescribing of
antimicrobial agents to control misuse and overuse of antibiotics with the aim of curbing antimicrobial resistance. There is need to initiate antimicrobial stewardship program at various levels in the health sector such as health facilities or hospitals in order to safeguard and sustain the current antimicrobial agents in use. In addition, oxazolidinones are potent
drugs in management of multidrug resistance (MDR) related infections and linezolid is already on the market and being considered as a drug of 'last resort' for the treatment of MDR bacterial infections. Therefore, to avert the development and rapid spread of drug resistance against linezolid and other oxazolidinone drugs, antimicrobial stewardship program needs to be established for critical monitoring and regulation of their use at all critical levels in the health system hierarchy, especially in resource limited countries.


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Author Biographies

Warren Chanda, Mulungushi University

School of Medicine and Health Sciences,
Department of Pathology and Microbiology, Livingstone campus

John Amos Mulemena, Mulungushi University

School of Medicine and Health Sciences, Livingstone

Mespa Manyepa, Copperbelt University

School of Medicine, Ndola

Kingsley Kamvuma, Mulungushi University

School of Medicine and Health Sciences, Livingstone