Histopathological and Immunohistochemical Characteristics of Breast Carcinomas in Uyo, Subtropical Region of Africa

  • Emmanuel Kunle Abudu University of Uyo Teaching Hospital, Uyo, AkwaIbom State; Department of Histopathology
  • Michael Olatunde Tanimowo University of Uyo Teaching Hospital, Uyo, AkwaIbom State; Department of Histopathology
  • Isaac Assam Udo University of Uyo Teaching Hospital, Uyo, Akwa Ibom State; Department of Surgery
  • Fatimah Biade Abdulkareem University of Lagos, College of Medicine, Department of Anatomic & Molecular Pathology, Lagos
Keywords: Histopathological, Immunohistochemical Characteristics, Breast cancer, Uyo

Abstract

Background: There is a relative dearth of data for immunohistochemical characteristics of breast carcinomas in cancer registries of Nigeria and some parts of Africa. A descriptive hospital based study, done over a year, involving three hospitals in Uyo rendering breast cancer care.


Objective: To determine the immunohistochemical-expression pattern of oestrogen receptor, progesterone receptor, and human epidermal receptor 2 and their relationship with histopathological features of invasive breast carcinomas in Uyo, Akwa Ibom State.


Materials and methods: Each specimen with an accompanying completely filled coded proforma form containing clinical characteristics of patients with breast cancer was received at the Histopathology Department for  subsequent histopathological and immunohistochemical  analysis.

Results: The age range for patients with breast carcinoma was 23 -70 years with a mean age at presentation of 43.07 ± 11.19 years. Invasive ductalcarcinoma was the commonest histological type accounting for 86.9 % of all  breast cancer. Positivity for oestrogen receptors, progesterone receptors and Her-2 were seen in 18.0%, 14.8%  and 32.8% of breast carcinomas respectively. Majority of breast carcinomas were triple negative phenotype (62.3%).
Conclusion: Majority of the invasive breast carcinomas in our environment were triple negative phenotype (62.3%).

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Author Biography

Emmanuel Kunle Abudu, University of Uyo Teaching Hospital, Uyo, AkwaIbom State; Department of Histopathology

Department of Histopathology

Published
2019-08-16
Section
Articles