Prevalence of Basal-like Breast Cancer among Indigenous Black Zambians at the University Teaching Hospital, Lusaka, Zambia

Background: Breast cancer comprises a group of very diverse diseases, which can be demonstrated at the molecular, histopathological and clinical levels. Gene expression studies using RNA microarray studies have categorised breast carcinomas into several classes. Of these basal-like tumour class has showed poor prognosis and  their  insensitivity  to  hormonal  therapy  makes therapeutic management difficult. Immunohistochemistry using certain Cytokeratins such as CK 5/6 has made it easier to identify these tumours allowing for better management.