Immunohistochemical Expression of Vitamin-D Receptor in Oral and Skin Squamous Cell Carcinoma of a Black African Subpopulation

Abstract

Objective: The nuclear vitamin D receptor (VDR) is involved in multiple pathways that have a role to play in the biology of cancer. Recent evidence indicates that the active form of vitamin D (1alpha, 25-dihydroxycholecalciferol) (VD) exhibits several anti-growth effects. Thus it is useful as an anti-neoplastic agent in several human malignancies.